Evaluation and Management of Gross Hematuria in Autosomal Dominant Polycystic Kidney Disease: A Point of Care Guide for Practicing Internists

Am J Med Sci. 2018 Aug;356(2):177-180. doi: 10.1016/j.amjms.2017.11.013. Epub 2017 Nov 28.


Gross hematuria is common in autosomal dominant polycystic kidney disease (ADPKD). It is an alarming symptom and may be the first manifestation of ADPKD. Cyst hemorrhage is a frequent cause of hematuria in ADPKD while other differential diagnoses include cyst infection, urinary tract infection, renal stones and an underlying malignancy. Knowledge of the precipitating factors and clinical presentation of these conditions will help practicing internists in performing an appropriate evaluation and management of these entities and their complications, as well as executing timely referrals to subspecialists when indicated.

Keywords: Autosomal dominant polycystic kidney disease; Gross hematuria; Malignancy in ADPKD; Renal cysts; Renal stones in ADPKD.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Hematuria* / diagnosis
  • Hematuria* / pathology
  • Hematuria* / physiopathology
  • Humans
  • Internship and Residency
  • Kidney Calculi / diagnosis
  • Kidney Calculi / pathology
  • Kidney Calculi / physiopathology
  • Male
  • Point-of-Care Systems*
  • Polycystic Kidney, Autosomal Dominant* / diagnosis
  • Polycystic Kidney, Autosomal Dominant* / pathology
  • Polycystic Kidney, Autosomal Dominant* / physiopathology
  • Practice Guidelines as Topic