IL-17A is functionally relevant and a potential therapeutic target in bullous pemphigoid

J Autoimmun. 2019 Jan;96:104-112. doi: 10.1016/j.jaut.2018.09.003. Epub 2018 Sep 13.


IL-17A has been identified as key regulatory molecule in several autoimmune and chronic inflammatory diseases followed by the successful use of anti-IL-17 therapy, e.g. in ankylosing spondylitis and psoriasis. Bullous pemphigoid (BP) is the most frequent autoimmune blistering disease with a high need for more specific, effective and safe treatment options. The aim of this study was to clarify the pathophysiological importance of IL-17A in BP. We found elevated numbers of IL-17A+ CD4+ lymphocytes in the peripheral blood of BP patients and identified CD3+ cells as major source of IL-17A in early BP skin lesions. IL17A and related genes were upregulated in BP skin and exome sequencing of 51 BP patients revealed mutations in twelve IL-17-related genes in 18 patients. We have subsequently found several lines of evidence suggesting a significant role of IL-17A in the BP pathogenesis: (i) IL-17A activated human neutrophils in vitro, (ii) inhibition of dermal-epidermal separation in cryosections of human skin incubated with anti-BP180 IgG and subsequently with anti-IL-17A IgG-treated leukocytes, (iii) close correlation of serum IL-17A levels and diseases activity in a mouse model of BP, (iv) IL17A-deficient mice were protected against autoantibody-induced BP, and (v) pharmacological inhibition of lL-17A reduced the induction of BP in mice. Our data give evidence for a pivotal role of IL-17A in the pathophysiology of BP and advocate IL-17A inhibition as potential novel treatment for this disease.

Keywords: Autoantibody; BP180; Bullous pemphigoid; IL-17A.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autoantibodies / immunology
  • CD4-Positive T-Lymphocytes / immunology*
  • Cells, Cultured
  • Disease Models, Animal
  • Exome Sequencing
  • Humans
  • Interleukin-17 / genetics
  • Interleukin-17 / metabolism*
  • Mice
  • Mice, Knockout
  • Mutation / genetics
  • Neutrophil Activation
  • Neutrophils / immunology*
  • Pemphigoid, Bullous / immunology*
  • Skin / metabolism*
  • Skin / pathology


  • Autoantibodies
  • Interleukin-17