Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles

Database (Oxford). 2018 Jan 1;2018:1-13. doi: 10.1093/database/bay083.

Abstract

Drug Target Commons (DTC) is a web platform (database with user interface) for community-driven bioactivity data integration and standardization for comprehensive mapping, reuse and analysis of compound-target interaction profiles. End users can search, upload, edit, annotate and export expert-curated bioactivity data for further analysis, using an application programmable interface, database dump or tab-delimited text download options. To guide chemical biology and drug-repurposing applications, DTC version 2.0 includes updated clinical development information for the compounds and target gene-disease associations, as well as cancer-type indications for mutant protein targets, which are critical for precision oncology developments.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Biological Assay
  • Data Mining
  • Databases, Protein
  • Drug Interactions*
  • Internet
  • Mutation / genetics
  • Software*
  • User-Computer Interface