Peptide hormone production in small cell lung carcinomas with particular reference to gastrin-releasing peptide

Jpn J Clin Oncol. 1986 Sep;16(3):235-41.


Tissues of 50 small cell lung carcinomas were examined for production of 17 peptide hormones. Only when the concentration of a peptide detected in the tumor was 10 pmol or more per g wet weight, was the peptide considered to be produced by the tumor. The frequency of production of at least one of these peptide hormones was 84%, and that of two or more hormones was 50%. These results indicate that peptide hormone production is a very common phenomenon in small cell lung carcinoma. Of the peptide hormones examined, gastrin-releasing peptide is produced with the highest frequency, suggesting that this peptide could play an important role in small cell lung carcinoma.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amino Acid Sequence
  • Bombesin / analysis
  • Carcinoma, Small Cell / metabolism*
  • Gastrin-Releasing Peptide
  • Hormones / analysis*
  • Humans
  • Lung Neoplasms / metabolism*
  • Peptides / analysis*
  • Radioimmunoassay


  • Hormones
  • Peptides
  • Gastrin-Releasing Peptide
  • Bombesin