Buffering chronic kidney disease with sodium bicarbonate

Clin Sci (Lond). 2018 Sep 16;132(17):1999-2001. doi: 10.1042/CS20180292. Print 2018 Sep 14.


The roles of the kidney are well defined, if there is a progressive loss in renal function, the kidney is no longer able to perform the listed tasks and chronic kidney disease (CKD) persists. In both clinical and experimental studies, NaHCO3 supplementation has been shown to improve glomerular filtration rate (GFR) as well as halt the progression toward end-stage renal disease (ESRD). In an article recently published in Clinical Science (vol 132 (11) 1179-1197), Ray et al. presented an intriguing and timely study, which investigates the mechanisms involved in the protection that follows oral NaHCO3 ingestion. Here we comment on their research findings.

Keywords: Dahl salt-sensitive rats; Hv1; alkali loading; tubular casts.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Glomerular Filtration Rate
  • Kidney Glomerulus
  • Proteinuria
  • Rats
  • Rats, Inbred Dahl
  • Renal Insufficiency, Chronic*
  • Sodium Bicarbonate*


  • Sodium Bicarbonate