The purpose of this study was to investigate the correlation of Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Interference (PI) score with traditionally collected visual analog scale (VAS) scores and to determine the influence of patient demographics on PROMIS PI and VAS scores. Patient demographics were collected, and PROMIS PI, PROMIS Physical Function (PF), and VAS questionnaires were distributed to 215 patients in orthopedic ambulatory clinics. The primary outcome was correlation between PROMIS PI and VAS questionnaires. The statistical method of seemingly unrelated regressions was used to identify significant predictors and strengths of correlation between PROMIS PI and conventional forms. The PROMIS PI score was highly correlated to conventional pain and functional scores, with each standard deviation increase in PROMIS PI score predicting a 16-point increase for pain-related VAS scores (current pain, pain at rest, pain during activity, pain at night), an 18-point decrease in satisfaction of function score, and a 6-point decrease in general health score. Each standard deviation increase in PROMIS PF score for black patients predicted a reduction of 11 points for current pain, 10 points for pain at rest, 10 points for pain during activity, and 12 points for pain at night scores. The PROMIS PI score consistently predicts changes in VAS pain scores and can be considered a useful, standardized tool for measuring pain for clinical and research purposes. [Orthopedics. 2018; 41(6):e813-e819.].
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