Successful Lung Re-transplant in a Patient with Cepacia Syndrome due to Burkholderia ambifaria

J Cyst Fibros. 2019 Jan;18(1):e1-e4. doi: 10.1016/j.jcf.2018.08.011. Epub 2018 Sep 14.


Chronic airway inflammation and infection drive morbidity and mortality among patients with cystic fibrosis (CF). While Haemophilus influenzae and Staphylococcus aureus predominate in children, the prevalence of Pseudomonas aeruginosa increases as patients age. Other bacteria, including species within the Burkholderia cepacia complex (Bcc), are also more prevalent among adults with CF. Species within the Bcc accelerate lung function decline and can trigger development of "cepacia syndrome," both before and after lung transplantation. As a result, some centers advise against lung transplantation for Bcc-infected patients; however, little is known about the relative virulence of uncommon Bcc species. We describe a successful lung re-transplant in a patient with CF, chronic Burkholderia ambifaria airway infection, and cepacia syndrome.

Keywords: Burkholderia ambifaria; Burkholderia cepacia complex; cystic fibrosis; lung transplantation.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bacteremia / diagnosis
  • Bacteremia / microbiology
  • Bacteremia / surgery*
  • Burkholderia / isolation & purification*
  • Burkholderia Infections / diagnosis
  • Burkholderia Infections / microbiology
  • Burkholderia Infections / surgery*
  • Cystic Fibrosis / diagnosis
  • Cystic Fibrosis / microbiology
  • Cystic Fibrosis / surgery*
  • Female
  • Humans
  • Lung / diagnostic imaging*
  • Lung / microbiology
  • Lung Transplantation*
  • Reoperation
  • Syndrome
  • Tomography, X-Ray Computed

Supplementary concepts

  • Burkholderia ambifaria