Genetic Analysis of Over 1 Million People Identifies 535 New Loci Associated With Blood Pressure Traits

Nat Genet. 2018 Oct;50(10):1412-1425. doi: 10.1038/s41588-018-0205-x. Epub 2018 Sep 17.

Abstract

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

Publication types

  • Meta-Analysis
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Pressure / genetics*
  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / genetics
  • Cells, Cultured
  • Female
  • Genetic Loci
  • Genetic Predisposition to Disease
  • Genetic Testing / methods
  • Genetics, Population / methods
  • Genome-Wide Association Study
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • Hypertension / genetics
  • Life Style
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Quantitative Trait Loci*
  • Risk Factors

Grant support