HLA-A, -B, -DRB1, -DQA1, and -DQB1 profile in a population from southern Brazil

HLA. 2018 Nov;92(5):298-303. doi: 10.1111/tan.13368.

Abstract

The aim of this study was to determine the allele and haplotype frequencies of HLA-A, -B, -DRB1, and -DQB1 in a self-declared White population from the north and northwestern state of Paraná, southern Brazil, and compare the data with populations worldwide. The genotyping was performed with a group of 641 individuals, based on PCR-SSO and -SSP methods, and allele and haplotype frequencies were estimated. Comparisons with European, African, Asian, and Amerindian populations were performed. The most frequent allelic groups, alleles and haplotypes were: HLA-A*02, HLA-B*35, HLA-DRB1*07:01, HLA-DQB1*03:01, and HLA-A*01/B*08/DRB1*03:01. The results reinforced a predominance of a European composition in the self-declared White population from the north and northwestern Paraná.

Keywords: genetic polymorphism; human leukocyte antigen (HLA); population studies.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Alleles
  • Brazil
  • Female
  • Gene Frequency
  • Genetics, Population*
  • HLA-A Antigens / genetics*
  • HLA-B Antigens / genetics*
  • HLA-DQ alpha-Chains / genetics*
  • HLA-DQ beta-Chains / genetics*
  • HLA-DRB1 Chains / genetics*
  • Haplotypes*
  • Healthy Volunteers
  • Humans
  • Male
  • Polymorphism, Genetic

Substances

  • HLA-A Antigens
  • HLA-B Antigens
  • HLA-DQ alpha-Chains
  • HLA-DQ beta-Chains
  • HLA-DQA1 antigen
  • HLA-DQB1 antigen
  • HLA-DRB1 Chains