The relationship between vitamin D level and organ‑specific autoimmune disorders in newly diagnosed type I diabetes mellitus

Bratisl Lek Listy. 2018;119(9):544-549. doi: 10.4149/BLL_2018_098.


Introduction: The purpose of our study is to determine vitamin D levels in patients with newly diagnosed type 1 DM, and assess the association of type 1 DM with organ-specific autoimmune disorders, as well as their association with vitamin D.

Material and methods: We included a total of 160 patients, of whom 50 were newly diagnosed with type 1 DM (group I), 50 were formerly diagnosed with type 1 DM (group II), and 60 were healthy controls (group III).

Results: The mean level of 25(OH)D was 14.6 ng/dL in group I, 12.1 ng/dL in group II, and 16.1 ng/dL in group III. In all diabetic patients, the 25(OH)D levels were lower than those of controls. The 25(OH)D median level was 11.4 ng/ml in all cases included into the study with ATD. In subjects without ATD, the latter level was 15.3 ng/ml. The difference was found to be statistically significant.

Conclusions: In this study, the vitamin D level was lower in (i) type 1 diabetic patients when compared with healthy subjects, (ii) all cases included to study with ATD when compared with patients without ATD, (iii) all APA-positive type 1 diabetic patients with ATD when compared with none (iv) APA-positive newly diagnosed type 1 diabetics when compared with those APA-negative (Tab. 7, Fig. 1, Ref. 30).

Keywords: anti-parietal antibody anti-tissue transglutaminase TG‑IgA.; autoimmune disease; type 1 diabetes mellitus; vitamin D.

MeSH terms

  • Adult
  • Autoimmune Diseases / blood*
  • Case-Control Studies
  • Diabetes Mellitus, Type 1 / blood*
  • Female
  • Humans
  • Male
  • Vitamin D / blood*
  • Young Adult


  • Vitamin D