Results of long term testosterone replacement therapy in men with abdominal obesity, erectile dysfunction and testosterone deficiency

Bratisl Lek Listy. 2018;119(9):577-580. doi: 10.4149/BLL_2018_061.


Introduction: In this article, the authors evaluate subjective and objective results of long testosterone replacement therapy (TRT) and possible risk.

Methods: In a single center study, the authors treated 69 men with testosterone deficiency syndrome (TDS). The average age was 57.84 years and the follow-up period was 94.62 months. All men had at beginning a complete urological and internal examination. All the men were treated with three-month i.m. injections of 1000 mg testosterone undecanoate. The men were regularly checked according to the EAU guidelines.

Results: All of the men on treatment felt much better. Weight and waist circumference during monitoring showed a mild improvement. Excellent results were on red blood cells. Glucose, HDL cholesterol, triglycerides had stable values. PSA slightly increased and testosterone was within the normal range. In two men during treatment, we found a prostate cancer (low risk). Bone mineral density (BMD) of lumbar spine revealed a significant improvement.

Conclusion: TRT had multiple positive effect on affected men with TDS. Our long-term results showed a long mild improvement during the time. Authors concluded that long term treatment had multiple benefit for affected men (Fig. 11, Ref. 13).

Keywords: Testosterone deficiency syndrome; abdominal obesity; erectile dysfunction; metabolic syndrome; testosterone replacement therapy long term follow up..

MeSH terms

  • Adult
  • Aged
  • Androgens / therapeutic use*
  • Bone Density
  • Erectile Dysfunction / drug therapy*
  • Follow-Up Studies
  • Hormone Replacement Therapy*
  • Humans
  • Male
  • Middle Aged
  • Obesity, Abdominal / drug therapy*
  • Prostate-Specific Antigen / blood
  • Testosterone / analogs & derivatives*
  • Testosterone / deficiency*
  • Testosterone / therapeutic use
  • Treatment Outcome


  • Androgens
  • Testosterone
  • Prostate-Specific Antigen
  • testosterone undecanoate