[Polymetastatic highly aggressive Small Cell Undifferentiated Neuroendocrine Carcinoma of Ascending Colon]

Cir Cir. 2018;86(5):446-449. doi: 10.24875/CIRU.18000058.
[Article in Spanish]

Abstract

Neuroendocrine carcinoma (NEC) of the colon is a rare and very aggressive tumor with poor prognosis. The current case report presents a 53-year-old male with a 6 cm × 10 cm ascending colon carcinoma, causing large intestine obstruction, with simultaneous multiple hepatic metastases and peritoneal carcinomatosis. Surgical resection of the primary tumor was performed, because of the bowel obstruction, to ameliorate the symptoms before the onset of chemotherapy. Histopathology revealed that the tumor was a small-cell undifferentiated NEC. During the post0operative period, the patient presented pulmonary metastases, and on the 36th post-operative day, death occurred due to respiratory failure.

El carcinoma neuroendocrino del colon es un tumor raro y muy agresivo, con mal pronóstico. Se presenta el caso de un hombre de 53 años con un carcinoma de colon ascendente de 6 × 10 cm que causa obstrucción del intestino grueso, con metástasis hepáticas múltiples simultáneas y carcinomatosis peritoneal. Se realizó la resección quirúrgica del tumor primario, debido a la obstrucción intestinal, para mejorar los síntomas antes del inicio de la quimioterapia. La histopatología reveló que el tumor era un carcinoma neuroendocrino indiferenciado de células pequeñas. Durante el posoperatorio, el paciente presentó metástasis pulmonares y el día 36 posoperatorio se produjo la muerte por insuficiencia respiratoria.

Keywords: Chromogranin; Colectomy; Colectomía; Cromogranina; Enolasa específica de neuronas; Neuroendocrine tumor; Neuron specific enolase; Tumor neuroendocrino.

Publication types

  • Case Reports

MeSH terms

  • Adenoma
  • Adrenal Gland Neoplasms
  • Carcinoma, Neuroendocrine / diagnostic imaging
  • Carcinoma, Neuroendocrine / pathology
  • Carcinoma, Neuroendocrine / secondary*
  • Carcinoma, Neuroendocrine / surgery
  • Colectomy / methods
  • Colonic Neoplasms / diagnostic imaging
  • Colonic Neoplasms / pathology*
  • Colonic Neoplasms / surgery
  • Fatal Outcome
  • Humans
  • Intestinal Obstruction / etiology
  • Intestinal Obstruction / surgery
  • Laparotomy
  • Liver Neoplasms / diagnostic imaging
  • Liver Neoplasms / secondary*
  • Lung Neoplasms / complications
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / secondary*
  • Male
  • Middle Aged
  • Neoplasm Invasiveness
  • Neoplasms, Second Primary
  • Peritoneal Neoplasms / diagnostic imaging
  • Peritoneal Neoplasms / secondary*
  • Respiratory Insufficiency / etiology
  • Tomography, X-Ray Computed