DNA Restriction Analysis of Adenovirus Prototypes 1 to 41

Arch Virol. 1986;91(3-4):277-90. doi: 10.1007/BF01314287.


DNA restriction patterns of all known human adenovirus prototypes (1 to 41), ordered according to subgenera A to F, are presented for restriction endonucleases BamHI, BglII, BstEII, HindIII, and SmaI. This catalogue is a prerequisite for typing of adenoviruses by DNA restriction analysis in diagnostic laboratories and for strain identification in reference laboratories. To determine the genetic relationship of human adenoviruses within a subgenus and between subgenera, a pairwise analysis of comigrating fragments was performed. Adenoviruses of subgenus C were closely related. Adenoviruses of subgenus B showed two related clusters of four types each, whereas the numerous serotypes of subgenus D did not show any corresponding clustering. Little comigration was observed between DNA restriction fragments from members of subgenus A or F respectively.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoviruses, Human / classification
  • Adenoviruses, Human / genetics*
  • Bacterial Proteins*
  • DNA Restriction Enzymes
  • DNA, Viral / analysis*
  • Deoxyribonuclease BamHI
  • Deoxyribonuclease HindIII
  • Deoxyribonucleases, Type II Site-Specific*
  • Genes, Viral*


  • Bacterial Proteins
  • DNA, Viral
  • DNA Restriction Enzymes
  • Deoxyribonuclease BamHI
  • Deoxyribonuclease HindIII
  • BglII endonuclease
  • Deoxyribonucleases, Type II Site-Specific
  • GGTNACC-specific type II deoxyribonucleases