Elucidating the developmental trajectories of GABAergic cortical interneuron subtypes

Abstract

GABAergic interneurons in the neocortex play pivotal roles in the feedforward and feedback inhibition that control higher order information processing and thus, malfunction in the inhibitory circuits often leads to neurodevelopmental disorders. Very interestingly, a large diversity of morphology, synaptic targeting specificity, electrophysiological properties and molecular expression profiles are found in cortical interneurons, which originate within the distantly located embryonic ganglionic eminences. Here, I will review the still ongoing effort to understand the developmental trajectories of GABAergic cortical interneuron subtypes.

Keywords: Clonal analysis; Fate mapping; Ganglionic eminence; MGE and CGE; Migration; Single cell RNA sequencing; Transcription factor.