Congenital Cytomegalovirus Infection and Maternal Systemic Lupus Erythematosus: A Case Report

Arthritis Rheum. 1986 Nov;29(11):1402-4. doi: 10.1002/art.1780291114.


We describe an infant with symptomatic congenital cytomegalovirus infection, who was born to a mother with active systemic lupus erythematosus. Infection in the child resulted from reactivation of maternal cytomegalovirus infection. The mother's use of prednisone may have contributed to the reactivation. The role of maternal immunosuppression in the acquisition of congenital viral infection by the neonate is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Cytomegalovirus Infections / congenital*
  • Cytomegalovirus Infections / etiology
  • Cytomegalovirus Infections / immunology
  • Drug Therapy, Combination
  • Female
  • Humans
  • Immune Tolerance / drug effects
  • Infant, Newborn
  • Lupus Erythematosus, Systemic / complications*
  • Lupus Erythematosus, Systemic / drug therapy
  • Lupus Erythematosus, Systemic / immunology
  • Prednisone / therapeutic use
  • Pregnancy
  • Pregnancy Complications / drug therapy*
  • Pregnancy Complications / immunology


  • Anti-Inflammatory Agents, Non-Steroidal
  • Prednisone