Stepwise oral immunotherapy for 10 days in an egg-white allergy mouse model did not ameliorate the severity of allergy but induced the production of allergen-specific IgA

Biosci Biotechnol Biochem. 2018 Dec;82(12):2176-2179. doi: 10.1080/09168451.2018.1517592. Epub 2018 Sep 19.

Abstract

We examined whether the stepwise oral immunotherapy (OIT) for 10 days ameliorates the severity of allergy and the biomarkers in an allergy mouse model. The OIT could not protect anaphylaxis symptoms after allergen challenges but promote the production of antibodies, especially allergen-specific IgA. It was suggested that this OIT influenced the function of immuno response against the allergen. Abbreviations: EW: egg white; IFC: intraperitoneal food challenge; IFN-γ: interferon-γ; IL: interleukin; OVA: ovalbumin; OM: ovomucoid; OFC: oral food challenge; OIT: oral immunotherapy.

Keywords: Oral immunotherapy; allergic mouse model; egg white.

MeSH terms

  • Administration, Oral
  • Anaphylaxis / prevention & control*
  • Animals
  • Desensitization, Immunologic / methods*
  • Disease Models, Animal
  • Egg Hypersensitivity / immunology*
  • Egg Hypersensitivity / therapy*
  • Egg White*
  • Female
  • Immunoglobulin A / biosynthesis*
  • Immunoglobulin A / immunology
  • Mice
  • Mice, Inbred BALB C
  • Severity of Illness Index

Substances

  • Immunoglobulin A