A sequence homology between the pX genes of HTLV-I/II and the murine IL-3 gene

FEBS Lett. 1986 Nov 24;208(2):231-5. doi: 10.1016/0014-5793(86)81023-7.

Abstract

Searching the protein sequence database for amino acid sequences homologous to the x-lor sequence in the pX region of human T-cell leukemia virus types I and II (HTLV-I/II), we found that there is a region of 38 amino acids where the murine interleukin 3 (IL-3) sequence has a 40% homology with the x-lor sequence. A statistical analysis shows that this homology is highly significant with a probability of 1.57 X 10(-10). The biological implication of this homology is discussed.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Deltaretrovirus / genetics*
  • Genes, Viral
  • Interleukin-3 / genetics*
  • Mice
  • Protein Conformation
  • Retroviridae Proteins / genetics*
  • Sequence Homology, Nucleic Acid

Substances

  • Interleukin-3
  • Retroviridae Proteins