Ion Man: GSDMD Punches Pores to Knock Out cGAS

Immunity. 2018 Sep 18;49(3):379-381. doi: 10.1016/j.immuni.2018.08.026.

Abstract

The pore-forming protein GSDMD promotes cytokine release and induces pyroptotic cell death. In this issue of Immunity, Banerjee et al. (2018) document how GSDMD triggers potassium efflux to inhibit cGAS-STING and prevent damaging interferon production after bacterial infection.

Publication types

  • Comment

MeSH terms

  • Cytosol
  • DNA
  • Homeostasis
  • Interferon Type I*
  • Nucleotidyltransferases / genetics
  • Pyroptosis

Substances

  • Interferon Type I
  • DNA
  • Nucleotidyltransferases