Diet-induced obesity and associated disorders are prevented by natural bioactive type 1 fish collagen peptides (Naticol®) treatment

J Physiol Biochem. 2018 Nov;74(4):647-654. doi: 10.1007/s13105-018-0650-0. Epub 2018 Sep 19.


To fight against metabolic disorders such as insulin resistance, new alimentary behaviors are developed. For instance, hyperproteined, gluten-free, or collagen-enriched diets could be preconized in order to reduce the consequences of obesity. In this aim, this study evaluates the potential effects of warm sea fish collagen peptides (Naticol®) on representative metabolic and inflammatory parameters. For that, male C57Bl6/J mice fed with either a chow- (CD) or high-fat diet (HFD) were submitted or not to specific collagen peptides in drinking water (4 g/kg bw/d) for 20 weeks. Weight, body composition, glucose tolerance, and insulin sensitivity were followed up. Effects of fish collagen peptides on various blood parameters reflecting the metabolism status were also measured (free fatty acids, triglycerides, cholesterol, hormones) together with adipocyte inflammation. Results showed that HFD-fed mice supplemented by fish collagen peptides exhibited a significant lower increase in body weight as soon as the twelfth week of treatment whereas no effect of the peptide was observed in CD fed mice. In line with this result, a weaker increase in fat mass in HFD-fed mice supplemented with Naticol® at both 9 and 18 weeks of treatment was also observed. In spite of this resistance to obesity promoted by fish collagen peptides treatment, no difference in glucose tolerance was found between groups whereas mice treated with Naticol® exhibited a lower basal glycemia. Also, even if no effect of the treatment on adipocyte lipolysis was found, a decrease of inflammatory cytokines was retrieved in collagen-supplemented group arguing for a potential better insulin sensitivity. Altogether, these results need to be completed but are the first describing a benefic role of warm sea fish collagen peptides in a context of metabolic disease paving the route for a potential utilization in human obesity-associated disorders.

Keywords: Adipokine; Adipose tissue; Collagen; Glycemia; Low-grade inflammation; Obesity.

MeSH terms

  • Adipose Tissue / immunology
  • Adipose Tissue / metabolism
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / metabolism
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Anti-Obesity Agents / adverse effects
  • Anti-Obesity Agents / chemistry
  • Anti-Obesity Agents / metabolism
  • Anti-Obesity Agents / therapeutic use*
  • Apelin / agonists
  • Apelin / genetics
  • Apelin / metabolism
  • Collagen / adverse effects
  • Collagen / chemistry
  • Collagen / metabolism
  • Collagen / therapeutic use*
  • Cytokines / antagonists & inhibitors
  • Cytokines / genetics
  • Cytokines / metabolism
  • Diet, High-Fat / adverse effects
  • Dietary Supplements* / adverse effects
  • Fish Proteins, Dietary / adverse effects
  • Fish Proteins, Dietary / chemistry
  • Fish Proteins, Dietary / metabolism
  • Fish Proteins, Dietary / therapeutic use*
  • Gene Expression Regulation
  • Glucose Intolerance / etiology
  • Glucose Intolerance / immunology
  • Glucose Intolerance / prevention & control
  • Insulin Resistance*
  • Lipolysis
  • Male
  • Mice, Inbred C57BL
  • Obesity / etiology
  • Obesity / metabolism
  • Obesity / physiopathology
  • Obesity / therapy*
  • Panniculitis / etiology
  • Panniculitis / immunology
  • Panniculitis / prevention & control
  • Peptide Fragments / adverse effects
  • Peptide Fragments / chemistry
  • Peptide Fragments / metabolism
  • Peptide Fragments / therapeutic use*
  • Weight Gain


  • Anti-Inflammatory Agents, Non-Steroidal
  • Anti-Obesity Agents
  • Apelin
  • Apln protein, mouse
  • Cytokines
  • Fish Proteins, Dietary
  • Peptide Fragments
  • Collagen