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Review
. 2018;1086:169-187.
doi: 10.1007/978-981-13-1117-8_11.

Aging Kidney and Aging-Related Disease

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Review

Aging Kidney and Aging-Related Disease

Zhongchi Li et al. Adv Exp Med Biol. .

Abstract

With the development of society and improvement of health care, the life span is much longer than before, which brings serious aging problems. Among all the aging problems, renal aging grows to be nonnegligible issue. The aging process of kidney is always accompanied with structural and functional changes. Molecular changes, including Klotho and Sirtuins, are the basic causes of phenotypical changes. Cell senescence and cell autophagy play fundamental roles in the process of renal aging. To effectively intervene in the process of renal aging, different methods have been tried separately, which could produce different effects. Effective intervention of renal aging could be meaningful for healthy state of the whole body.

Keywords: Autophagy; Cell senescence; Epigenetic regulation; Renal aging.

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