Bisphenol-A in Breast Adipose Tissue of Breast Cancer Cases and Controls

Environ Res. 2018 Nov;167:735-738. doi: 10.1016/j.envres.2018.08.033. Epub 2018 Aug 31.

Abstract

We evaluated whether bisphenol-A (BPA) could be quantified in breast adipose tissue samples provided by 36 breast cancer mastectomy patients and 14 reduction mammoplasty patients. Samples of breast adipose tissue were collected and BPA concentration was quantified using HPLC-ESI-MS/MS. BPA was detectable above the limit of quantitation of 0.38 ng/g in 30.6% of samples. BPA concentrations varied within- and between breasts and were similar between cases and controls (0.39 vs 0.41 ng/g, p = 0.74).

Keywords: Adipose; Bisphenol-A; Breast; Cancer; Endocrine disruption.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / drug effects
  • Benzhydryl Compounds / toxicity*
  • Breast Neoplasms* / etiology
  • Chromatography, High Pressure Liquid
  • Humans
  • Mastectomy
  • Phenols / toxicity*
  • Tandem Mass Spectrometry

Substances

  • Benzhydryl Compounds
  • Phenols
  • bisphenol A