POSTAR2: deciphering the post-transcriptional regulatory logics

Nucleic Acids Res. 2019 Jan 8;47(D1):D203-D211. doi: 10.1093/nar/gky830.


Post-transcriptional regulation of RNAs is critical to the diverse range of cellular processes. The volume of functional genomic data focusing on post-transcriptional regulation logics continues to grow in recent years. In the current database version, POSTAR2 (, we included the following new features and data: updated ∼500 CLIP-seq datasets (∼1200 CLIP-seq datasets in total) from six species, including human, mouse, fly, worm, Arabidopsis and yeast; added a new module 'Translatome', which is derived from Ribo-seq datasets and contains ∼36 million open reading frames (ORFs) in the genomes from the six species; updated and unified post-transcriptional regulation and variation data. Finally, we improved web interfaces for searching and visualizing protein-RNA interactions with multi-layer information. Meanwhile, we also merged our CLIPdb database into POSTAR2. POSTAR2 will help researchers investigate the post-transcriptional regulatory logics coordinated by RNA-binding proteins and translational landscape of cellular RNAs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Binding Sites
  • Computational Biology* / methods
  • Databases, Genetic*
  • Gene Expression Regulation*
  • Humans
  • Immunoprecipitation
  • Molecular Sequence Annotation
  • Open Reading Frames
  • Protein Binding
  • RNA Processing, Post-Transcriptional*
  • RNA-Binding Proteins / metabolism
  • Sequence Analysis, DNA
  • Web Browser


  • RNA-Binding Proteins