Sucrosomial ® Iron Supplementation in Mice: Effects on Blood Parameters, Hepcidin, and Inflammation

Nutrients. 2018 Sep 21;10(10):1349. doi: 10.3390/nu10101349.

Abstract

Sucrosomial® Iron is a recently developed formulation to treat iron deficiency based on ferric pyrophosphate covered by a matrix of phospholipids plus sucrose esters of fatty acids. Previous data indicated that Sucrosomial® Iron is efficiently absorbed by iron-deficient subjects, even at low dosage, and without side effects. Its structural properties may suggest that it is absorbed by an intestinal pathway which is different to the one used by ionic iron. Although, studies in vitro showed that Sucrosomial® Iron is readily absorbed, no animal models have been established to study this important aspect. To this aim, we induced iron deficient anemia in mice by feeding them with a low-iron diet, and then we treated them with either Sucrosomial® Iron or sulfate iron by gavage for up to two weeks. Both iron formulations corrected anemia and restored iron stores in a two-week period, but with different kinetics. Ferrous Sulfate was more efficient during the first week and Sucrosomial® Iron in the second week. Of note, when given at the same concentrations, Ferrous Sulfate induced the expression of hepcidin and four different inflammatory markers (Socs3, Saa1, IL6 and CRP), while Sucrosomial® Iron did not. We conclude that anemic mice are interesting models to study the absorption of oral iron, and that Sucrosomial® Iron is to be preferred over Ferrous Sulfate because of similar absorption but without inducing an inflammatory response.

Keywords: Sucrosomial® Iron; iron absorption; iron deficient anemia; mouse models; oral iron.

MeSH terms

  • Anemia, Iron-Deficiency / blood
  • Anemia, Iron-Deficiency / drug therapy*
  • Animals
  • Diphosphates / pharmacokinetics
  • Diphosphates / pharmacology
  • Diphosphates / therapeutic use*
  • Disease Models, Animal
  • Female
  • Ferric Compounds / pharmacokinetics
  • Ferric Compounds / pharmacology
  • Ferric Compounds / therapeutic use*
  • Ferrous Compounds / adverse effects
  • Ferrous Compounds / therapeutic use
  • Hep G2 Cells
  • Hepcidins / metabolism*
  • Humans
  • Inflammation / etiology
  • Inflammation / prevention & control*
  • Intestinal Absorption*
  • Intestines
  • Iron / blood
  • Iron / pharmacokinetics
  • Iron / pharmacology
  • Iron / therapeutic use
  • Iron Deficiencies*
  • Mice, Inbred BALB C

Substances

  • Diphosphates
  • Ferric Compounds
  • Ferrous Compounds
  • Hepcidins
  • ferrous sulfate
  • Iron
  • ferric pyrophosphate