Chromatin Domains Go on Repeat in Disease

Cell. 2018 Sep 20;175(1):38-40. doi: 10.1016/j.cell.2018.08.068.


TAD boundaries are insulators of genomic neighborhoods. In this issue, Sun et al. show that disease-associated tandem repeats are located to TAD boundaries and affect their insulation. The findings have important implications for TAD function and mechanisms underlying diseases such as fragile X syndrome and Huntington's disease.

Publication types

  • Comment

MeSH terms

  • Chromatin*
  • Fragile X Syndrome / genetics*
  • Genome
  • Genomics
  • Humans
  • Microsatellite Repeats


  • Chromatin