The emerging role of ADAM metalloproteinases in immunity

Nat Rev Immunol. 2018 Dec;18(12):745-758. doi: 10.1038/s41577-018-0068-5.


Proteolysis is an irreversible physiological process that can result in the termination or activation of protein function. Many transmembrane proteins that are involved in the cellular communication between immune cells and structural cells - for example, Notch, CD23, CD44, and membrane-anchored cytokines and their receptors - are cleaved by the ADAM (a disintegrin and metalloproteinase) family of enzymes. Here, we review recent insights into the molecular activation, substrate specificity and function of ADAM proteins in the development and regulation of the immune system, with a particular focus on the roles of ADAM10 and ADAM17.

Publication types

  • Review

MeSH terms

  • ADAM10 Protein / immunology*
  • ADAM17 Protein / immunology*
  • Amyloid Precursor Protein Secretases / immunology*
  • B-Lymphocytes / immunology
  • Gene Expression Regulation / immunology
  • Humans
  • Immune System / physiology*
  • Membrane Proteins / immunology*
  • Myeloid Cells / immunology
  • Proteolysis*
  • Receptors, Notch / metabolism*
  • T-Lymphocytes / immunology


  • Membrane Proteins
  • Receptors, Notch
  • Amyloid Precursor Protein Secretases
  • ADAM10 Protein
  • ADAM10 protein, human
  • ADAM17 Protein
  • ADAM17 protein, human