Aromatic-turmerone ameliorates imiquimod-induced psoriasis-like inflammation of BALB/c mice

Int Immunopharmacol. 2018 Nov:64:319-325. doi: 10.1016/j.intimp.2018.09.015. Epub 2018 Sep 19.


Psoriasis is a usual immune-mediated inflammatory skin disease with undefined pathogenesis. Aromatic-turmerone (ATM) is a mainly constituent of essential oil from Curcuma longa L. It has been shown to exhibit strong anti-oxidant, anti-tumor activities and anti-inflammatory effects. In this study, we investigated the effects of ATM on imiquimod (IMQ)-induced psoriasis-like BALB/c mice and its molecular mechanisms for anti-inflammatory effect. ATM showed inhibition of the transfer of CD8+ T cells in epidermis, and reduced expression of NF-κB and COX-2 as well as phosphorylation of p38 MAPK. It also decreased the level of TNF-α and IL-6, and down-regulates IL-17 IL-22 and IL-23 mRNA synthesis. Notably, we demonstrated that topically applied ATM alleviated skin inflammation in IMQ-induced mice. These results indicate that ATM, a natural active compound exhibits anti-inflammatory activity and is a promising candidate molecule to treat inflammatory skin diseases, such as psoriasis.

Keywords: Anti-inflammation; Aromatic-turmerone; Imiquimod; Proinflammatory cytokines; Psoriasis.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / therapeutic use*
  • CD8-Positive T-Lymphocytes / drug effects
  • CD8-Positive T-Lymphocytes / immunology
  • Cyclooxygenase 2 / analysis
  • Cytokines / analysis
  • Female
  • Imiquimod / toxicity*
  • Ketones / pharmacology
  • Ketones / therapeutic use*
  • Mice
  • Mice, Inbred BALB C
  • NF-kappa B / analysis
  • Psoriasis / drug therapy*
  • Psoriasis / immunology
  • Sesquiterpenes / pharmacology
  • Sesquiterpenes / therapeutic use*
  • p38 Mitogen-Activated Protein Kinases / metabolism


  • Anti-Inflammatory Agents
  • Cytokines
  • Ketones
  • NF-kappa B
  • Sesquiterpenes
  • ar-turmerone
  • Cyclooxygenase 2
  • p38 Mitogen-Activated Protein Kinases
  • Imiquimod