Ethnic differences in the prevalence of diabetes in underweight and normal weight individuals: The CARRS and NHANES studies

Diabetes Res Clin Pract. 2018 Dec;146:34-40. doi: 10.1016/j.diabres.2018.09.011. Epub 2018 Sep 20.

Abstract

Aims: Type 2 diabetes in lean individuals has recently come to attention. We assessed type 2 diabetes prevalence and the associated risk factors in underweight and normal weight individuals in two ethnic populations.

Methods: We conducted cross-sectional analyses, using representative samples of 4930 Asian Indians from the CARRS-Chennai Study and 2868 Whites from the NHANES Survey. Diabetes was defined as use of glucose lowering medication, fasting glucose ≥126 mg/dl, or 2 h glucose ≥200 mg/dl. Body mass index (BMI) was classified using WHO standard criteria.

Results: Prevalence of type 2 diabetes by BMI varied by ethnicity and sex. In men, type 2 diabetes prevalence was 5.4% and 23.5% in underweight and normal weight Asian Indians and 0.0% and 6.1% in underweight and normal weight Whites. In women, the prevalence was 5.6% and 13.6% in underweight and normal weight Asian Indians and 2.3% and 2.8% in underweight and normal weight Whites. Adjustment for waist circumference, insulin resistance, and insulin secretion did not explain the increased prevalence in Asian Indians.

Conclusions: These findings suggest significant ethnic differences in type 2 diabetes prevalence without overweight or obesity. Future studies should examine the pathophysiology of type 2 diabetes development in lean individuals.

Keywords: Asian Indian; Body mass index; Ethnicity; Normal weight; Type 2 diabetes; Underweight.

Publication types

  • Multicenter Study

MeSH terms

  • Adult
  • Asian Continental Ancestry Group / statistics & numerical data*
  • Body Mass Index
  • Cohort Studies
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 2 / epidemiology*
  • Diabetes Mellitus, Type 2 / ethnology*
  • European Continental Ancestry Group / statistics & numerical data*
  • Female
  • Humans
  • India
  • Male
  • Middle Aged
  • Obesity / epidemiology*
  • Prevalence
  • Risk Factors
  • Thinness / epidemiology*
  • United States
  • Young Adult