Novel electrospun polycaprolactone/graphene oxide/Fe3O4 nanocomposites for biomedical applications

Colloids Surf B Biointerfaces. 2018 Dec 1;172:718-727. doi: 10.1016/j.colsurfb.2018.09.035. Epub 2018 Sep 15.


In this study, one of the most promising methods of tailoring a composite scaffold material in nano sized diameters, electrospinning method were used to produce Polycaprolactone (PCL)/Graphene Oxide (GO)/Iron(II, III) Oxide (Fe3O4) nanocomposite fibers as biocompatible scaffolds for biomedical applications. Products were analyzed by scanning electron microscopy (SEM) for morphological analysis of the electrospun nanocomposites and Fourier Transform Infrared Spectroscopy (FTIR) was used to determine functional groups of the PCL, GO, and Fe3O4 materials in the electrospun nanocomposites. For physical properties, viscosity, density, permittivity, dielectric loss and liquid and solid state alternating current conductivity, measurements were done for each nanocomposite fibers. Effects of concentration percentage of GO on permittivity, dielectric loss and AC conductivity have been analyzed by using measured and calculated data. Trend lines have been drawn for permittivity, dielectric loss and conductivity via concentration percentage of GO. The relation between ac conductivity and frequency have been studied for each concentration percentage of GO and interpretations have been done by using the obtained results.

Keywords: Biomedical engineering; Electrical properties; Electrospinning; Graphene oxides; PCL.

MeSH terms

  • Animals
  • Biomedical Technology / methods*
  • Cell Line, Tumor
  • Cell Survival
  • Ferric Compounds / chemistry*
  • Graphite / chemistry*
  • Humans
  • Mice
  • NIH 3T3 Cells
  • Nanocomposites / chemistry*
  • Nanocomposites / ultrastructure
  • Polyesters / chemistry*
  • Spectroscopy, Fourier Transform Infrared
  • Spectrum Analysis, Raman
  • Tensile Strength
  • Tissue Engineering / methods
  • Tissue Scaffolds / chemistry


  • Ferric Compounds
  • Polyesters
  • graphene oxide
  • ferric oxide
  • polycaprolactone
  • Graphite