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, 2018, 6015351

Biological Activities, Health Benefits, and Therapeutic Properties of Avenanthramides: From Skin Protection to Prevention and Treatment of Cerebrovascular Diseases


Biological Activities, Health Benefits, and Therapeutic Properties of Avenanthramides: From Skin Protection to Prevention and Treatment of Cerebrovascular Diseases

Andrea Perrelli et al. Oxid Med Cell Longev.


Oat (Avena sativa) is a cereal known since antiquity as a useful grain with abundant nutritional and health benefits. It contains distinct molecular components with high antioxidant activity, such as tocopherols, tocotrienols, and flavanoids. In addition, it is a unique source of avenanthramides, phenolic amides containing anthranilic acid and hydroxycinnamic acid moieties, and endowed with major beneficial health properties because of their antioxidant, anti-inflammatory, and antiproliferative effects. In this review, we report on the biological activities of avenanthramides and their derivatives, including analogs produced in recombinant yeast, with a major focus on the therapeutic potential of these secondary metabolites in the treatment of aging-related human diseases. Moreover, we also present recent advances pointing to avenanthramides as interesting therapeutic candidates for the treatment of cerebral cavernous malformation (CCM) disease, a major cerebrovascular disorder affecting up to 0.5% of the human population. Finally, we highlight the potential of foodomics and redox proteomics approaches in outlining distinctive molecular pathways and redox protein modifications associated with avenanthramide bioactivities in promoting human health and contrasting the onset and progression of various pathologies. The paper is dedicated to the memory of Adelia Frison.


Figure 1
Figure 1
Chemical structure and names of some natural (Avn), synthetic (Tranilast), and recombinant (YAvn) avenanthramides. Avns are low molecular weight phenolic compounds consisting of an anthranilic acid linked to a hydroxycinnamic acid with an amide bond. Different forms of Avns have been either extracted from oats, produced by chemical synthesis, or generated by recombinant DNA techniques in yeast cells.
Figure 2
Figure 2
Bioactivities and potential health benefits of avenanthramides. Both natural, synthetic, and recombinant avenanthramides have been shown to exhibit strong antioxidant, anti-inflammatory, and antiproliferative activities, which may provide protection against various cellular dysfunctions and human pathologies, including aging-related diseases.

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