A contemporary view of platelet-rich plasma therapies: moving toward refined clinical protocols and precise indications

Regen Med. 2018 Sep;13(6):717-728. doi: 10.2217/rme-2018-0042. Epub 2018 Sep 24.


The positive extensive clinical experience with platelet-rich plasma (PRP) in different medical areas has prompted researchers to explore clinical opportunities for optimized PRP therapies. PRP is safe but we have to make it more effective. The growing diversity of formulations and presentations enrich the field of PRP research and offer hope to refine clinical indications. Moving toward targeting the right disease phenotypes with the right PRP formulation or combination product (PRP + cell products) can offer opportunities to change treatment options in osteoarthritis and nonhealing wounds. Both are active areas of research that could offer opportunities, although cost efficacy is still an open question. Our position is to believe that these serious disease areas are likely to benefit from PRP therapies.

Keywords: cell therapies; chronic wound; functionality; healing; osteoarthritis; pain; platelet-rich plasma; regenerative medicine.

Publication types

  • Review

MeSH terms

  • Blood Transfusion / methods
  • Blood Transfusion / standards
  • Clinical Protocols
  • Humans
  • Platelet-Rich Plasma*
  • Regenerative Medicine / methods*
  • Regenerative Medicine / trends
  • Transfusion Reaction
  • Wound Healing