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. 2018 Sep 15;32(9):470-4, CV3.

Complications of Androgen Deprivation Therapy in Men With Prostate Cancer

  • PMID: 30248169
Free article

Complications of Androgen Deprivation Therapy in Men With Prostate Cancer

Tejas Patil et al. Oncology (Williston Park). .
Free article

Abstract

The standard treatment for men with metastatic prostate cancer is androgen deprivation therapy (ADT). This therapy is associated with a multitude of side effects that can impact quality of life. These include vasomotor complications (in particular, hot flushes), sexual dysfunction and gynecomastia, osteoporosis, metabolic syndrome, and depression. Additionally, ADT has been associated with neurocognitive deficits, thromboembolic disease, and cardiovascular disease, although the data regarding the latter associations are mixed. This article summarizes the key side effects associated with ADT and discusses strategies to optimize management.

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