Vaccine Update: Recent Progress With Novel Vaccines, and New Approaches to Safety Monitoring and Vaccine Shortage

J Clin Pharmacol. 2018 Oct;58 Suppl 10:S123-S139. doi: 10.1002/jcph.1140.


Vaccines are increasingly based on new constructs, new technologies, and new compounds. Novel immunization programs are rapidly implemented globally. In this article, we highlight selected hot topics of this highly dynamic and broad field of scientific and public health development. The first section focuses on novel vaccines including malaria, dengue, serogroup B meningococcal, and respiratory syncytial virus vaccines and antibodies. The second section is addressing emerging strategies and programmatic challenges including maternal immunization, integrated mother-child safety monitoring, and finally coping strategies with vaccine shortages.

Keywords: antibodies; dengue; malaria; maternal immunization; meningitis; prevention; respiratory syncytial vaccine; safety; vaccine shortage; virus.

MeSH terms

  • Antibodies, Viral / immunology
  • Dengue / prevention & control
  • Drug Development
  • Europe
  • Female
  • Humans
  • Immunization / adverse effects
  • Malaria / prevention & control
  • Meningitis, Meningococcal / prevention & control
  • Pregnancy
  • Respiratory Syncytial Virus Infections / prevention & control
  • Respiratory Syncytial Viruses / immunology
  • Vaccines / supply & distribution*
  • Vaccines / therapeutic use*


  • Antibodies, Viral
  • Vaccines