Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Filters applied. Clear all
, 204, 96-103

Metabolic Abnormalities and Low Dietary Omega 3 Are Associated With Symptom Severity and Worse Functioning Prior to the Onset of Psychosis: Findings From the North American Prodrome Longitudinal Studies Consortium

Metabolic Abnormalities and Low Dietary Omega 3 Are Associated With Symptom Severity and Worse Functioning Prior to the Onset of Psychosis: Findings From the North American Prodrome Longitudinal Studies Consortium

Kristin S Cadenhead et al. Schizophr Res.

Abstract

Objective: Patients with schizophrenia have a high prevalence of metabolic disorders and cardiovascular mortality. It is possible that a vulnerability to metabolic abnormalities is associated with risk for psychosis, symptoms and functionality. In this study, we evaluate demographic information, cardiometabolic indices, symptoms and functioning in an antipsychotic free cohort at Clinical High Risk (CHR) for psychosis from the NAPLS Omega 3 fatty acid clinical trial.

Method: Subjects received physical exams and metabolic monitoring prior to randomization into the Omega 3 versus Placebo trial. Anthropometrical measures, vital signs, glucose, and lipids were assessed along with symptoms, functioning, dietary Omega 3 fatty acids, erythrocyte polyunsaturated fatty acid content and a measure of lipid peroxidation (TBARS, Thiobarbituric acid-reactive substances).

Results: The sample included 113 CHR subjects (42.1% female; 17.5% Latino) ages 12-29. The mean BMI was 24.3 with a trend toward higher BMI and a higher incidence of metabolic syndrome in Latino subjects; 36% of the sample was obese/overweight; 37.6% met criteria for prehypertension/hypertension; 4.2% met criteria for prediabetes/diabetes; 9.6% showed evidence of insulin resistance and 44.7% had dyslipidemia. The TBARS was elevated at 9.8 μM ± 6.1 (normal 1.86-3.94 μM). Metabolic parameters and a diet low in Omega 3 rich foods were significantly associated with prodromal symptoms and poor functioning.

Conclusions: CHR subjects show a high percentage of metabolic abnormalities prior to exposure to antipsychotic medication. These findings reinforce that early detection of metabolic disturbances and food insecurity is crucial since these factors are modifiable with the potential for significant gains in terms of quality of life, physical and mental health.

Keywords: Clinical high risk; Fatty acid; Metabolic; Omega 3; Oxidative stress.

Conflict of interest statement

Conflicts of Interest: Authors report no conflicts of interests related to this study

Similar articles

Cited by 3 PubMed Central articles

References

    1. Abduljawad KA, Langley RW, Bradshaw CM, Szabadi E, 2001. Effects of clonidine and diazepam on prepulse inhibition of the acoustic startle response and the N1/P2 auditory evoked potential in man. J Psychopharmacol 15(4), 237–242. - PubMed
    1. Arvindakshan M, Sitasawad S, Debsikdar V, Ghate M, Evans D, Horrobin DF, Bennett C, Ranjekar PK, Mahadik SP, 2003. Essential polyunsaturated fatty acid and lipid peroxide levels in never-medicated and medicated schizophrenia patients. Biol Psychiatry 53(1), 56–64. - PubMed
    1. Assies J, Mocking RJ, Lok A, Ruhe HG, Pouwer F, Schene AH, 2014. Effects of oxidative stress on fatty acid- and one-carbon-metabolism in psychiatric and cardiovascular disease comorbidity. Acta psychiatrica Scandinavica 130(3), 163–180. - PMC - PubMed
    1. Brown S, 1997. Excess mortality of schizophrenia. A meta-analysis. Br J Psychiatry 171, 502–508. - PubMed
    1. Buchholz S, Morrow AF, Coleman PL, 2008. Atypical antipsychotic-induced diabetes mellitus: an update on epidemiology and postulated mechanisms. Intern Med J 38(7), 602–606. - PubMed

Publication types

Feedback