Evaluating continuous blood coagulopathy in assessing the severity of acute colitis in Thoroughbred racehorses

J Equine Sci. 2018 Sep;29(3):79-85. doi: 10.1294/jes.29.79. Epub 2018 Sep 19.

Abstract

Although severe blood coagulopathy in horses with acute colitis causes multiple organ failure, which may be fatal, few studies have focused on the correlation between the fluctuations of coagulation parameters and severity of colitis. In this study, we evaluated the fluctuations of coagulation parameters in 14 Thoroughbred racehorses with acute colitis for 5 days from the day of hospitalization and compared them between 5 survivors and 9 non-survivors. Noteworthy features in the non-survivors were that antithrombin activity and fibrin degradation products continuously decreased and increased, respectively, for 4 days or more and that thrombin-antithrombin complexes increased in the last 2 days before death. Thus, these parameters should be continuously monitored to observe these fluctuations in assessing the severity of acute colitis.

Keywords: Thoroughbred; antithrombin activity; colitis; thrombin-antithrombin complex.