CHMP4C: A novel regulator of the mitotic spindle checkpoint

Mol Cell Oncol. 2018 Apr 11;5(3):e1445944. doi: 10.1080/23723556.2018.1445944. eCollection 2018.

Abstract

The mitotic spindle checkpoint delays anaphase onset until all chromosomes have achieved stable kinetochore-microtubule attachments. Here, we discuss recent findings showing that CHMP4C, a component of the endosomal sorting complex required for transport (ESCRT) machinery, protects human cells against chromosome missegregation by promoting localisation of the ROD-ZW10-ZWILCH (RZZ) spindle checkpoint complex to unattached kinetochores.

Keywords: Biology of malignant cells; CHMP4C; ESCRT; RZZ; ZW10; mitosis; spindle checkpoint.

Grant support

Worldwide Cancer Research, Fondation Sante.