A novel mechanism for the prevention of transcription replication conflicts

Mol Cell Oncol. 2018 Mar 28;5(3):e1451233. doi: 10.1080/23723556.2018.1451233. eCollection 2018.

Abstract

Transcription and replication complexes can coincide in space and time. Such coincidences may result in collisions that trigger genomic instability. The phosphorylation of Mrc1 by different signaling kinases is part of a general mechanism that serves to delay replication in response to different stresses that trigger a massive transcriptional response in S phase. This mechanism prevents Transcription-Replication Conflicts and maintains genomic integrity in response to unscheduled massive transcription during S phase.

Keywords: Cellular stress; Mrc1; genomic instability; signaling kinases; transcription replication conflicts.

Grant support

BC is a recipient of an FPI fellowship. The FP and EdN's laboratory is supported by grants from the Spanish Ministry of Economy and Competitiveness (BFU2015-64437-P and FEDER, BFU2014-52125-REDT, and BFU2014-51672-REDC to FP; BFU2017-85152-P and FEDER to EdN), the Catalan Government (2017 SGR 799), the Fundación Botín, and by the Banco Santander through its Santander Universities Global Division to FP. FP is a recipient of an ICREA Acadèmia (Generalitat de Catalunya). The department is supported by Unidad de Excelencia Maria de Maeztu, MDM-2014-0370.