TEKT4 Promotes Papillary Thyroid Cancer Cell Proliferation, Colony Formation, and Metastasis through Activating PI3K/Akt Pathway

Endocr Pathol. 2018 Dec;29(4):310-316. doi: 10.1007/s12022-018-9549-0.


Thyroid carcinoma is the most common malignancy of the endocrine system worldwide, but its molecular mechanisms remain unclear. Some diseases are associated with TEKT4 gene. However, its role in thyroid carcinoma has yet to be fully examined. This study was designed to investigate the function of TEKT4 in papillary thyroid cancer (PTC). The effect of TEKT4 on aggressive behavior of PTC cell lines, namely, TPC1 and BCPAP, transfected with small interfering RNA was identified through cell proliferation, colony formation, migration, and invasion. Our previous study revealed that TEKT4 may be vital in PTC. In in vitro experiments, TEKT4 downregulation suppressed cell proliferation, colony formation, cell migration, and invasion. Our data also indicated that tumor-suppressing role of TEKT4 knockdown in PTC cell lines was associated with the silence of the PI3K/Akt pathway. Our study revealed that TEKT4 shows important biological implications and is worthy of further study.

Keywords: Metastasis; PI3K/Akt pathway; Papillary thyroid cancer; TEKT4.

MeSH terms

  • Adult
  • Cell Line, Tumor
  • Cell Proliferation / genetics
  • Female
  • Humans
  • Male
  • Microtubule Proteins / genetics*
  • Middle Aged
  • Mutation
  • Neoplasm Invasiveness / genetics
  • Signal Transduction / genetics
  • Thyroid Cancer, Papillary / genetics*
  • Thyroid Cancer, Papillary / pathology*
  • Thyroid Neoplasms / genetics*
  • Thyroid Neoplasms / pathology*


  • Microtubule Proteins
  • tektins