Mannose-Functionalized Nanoscaffolds for Targeted Delivery in Biomedical Applications

Chem Asian J. 2018 Nov 16;13(22):3448-3459. doi: 10.1002/asia.201801088. Epub 2018 Oct 12.

Abstract

Targeted drug delivery by nanomaterials has been extensively investigated as an effective strategy to surmount obstacles in the conventional treatment of cancer and infectious diseases, such as systemic toxicity, low drug efficacy, and drug resistance. Mannose-binding C-type lectins, which primarily include mannose receptor (MR, CD206) and dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), are highly expressed on various cancer cells, endothelial cells, macrophages, and dendritic cells (DCs), which make them attractive targets for therapeutic effect. Mannosylated nanomaterials hold great potential in cancer and infection treatment on account of their direct therapeutic effect on targeted cells, modulation of the tumor microenvironment, and stimulation of immune response through antigen presentation. This review presents the recent advances in mannose-based targeted delivery nanoplatforms incorporated with different therapies in the biomedical field.

Keywords: cancer; drug delivery; gene therapy; mannose receptors; nanostructures.

Publication types

  • Review

MeSH terms

  • Antibodies, Monoclonal / chemistry
  • Antibodies, Monoclonal / therapeutic use
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / therapeutic use
  • Cell Adhesion Molecules / chemistry
  • Cell Adhesion Molecules / metabolism
  • Drug Carriers / chemistry
  • Humans
  • Lectins, C-Type / chemistry
  • Lectins, C-Type / metabolism
  • Mannose / chemistry
  • Mannose / metabolism*
  • Mannose-Binding Lectins / metabolism
  • Nanostructures / chemistry*
  • Neoplasms / drug therapy
  • Neoplasms / pathology
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / therapeutic use
  • Receptors, Cell Surface / chemistry
  • Receptors, Cell Surface / metabolism

Substances

  • Antibodies, Monoclonal
  • Antineoplastic Agents
  • Cell Adhesion Molecules
  • DC-specific ICAM-3 grabbing nonintegrin
  • Drug Carriers
  • Lectins, C-Type
  • Mannose-Binding Lectins
  • Photosensitizing Agents
  • Receptors, Cell Surface
  • mannose receptor
  • Mannose