Metal-Mediated Functionalization of Natural Peptides and Proteins: Panning for Bioconjugation Gold

Angew Chem Int Ed Engl. 2019 May 6;58(19):6176-6199. doi: 10.1002/anie.201807536. Epub 2019 Mar 4.


Selective modification of natural proteins is a daunting methodological challenge and a stringent test of selectivity and reaction scope. There is a continued need for new reactivity and new selectivity concepts. Transition metals exhibit a wealth of unique reactivity that is orthogonal to biological reactions and processes. As such, metal-based methods play an increasingly important role in bioconjugation. This Review examines metal-based methods as well as their reactivity and selectivity for the functionalization of natural proteins and peptides.

Keywords: bioinorganic chemistry; metalation; peptides; protein modification; transition metals.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Alkylation
  • Amino Acids / chemistry
  • Catalysis
  • Coordination Complexes / chemistry
  • Gold / chemistry
  • Metals / chemistry*
  • Oxidation-Reduction
  • Peptides / chemistry*
  • Peptides / metabolism
  • Proteins / chemistry*
  • Proteins / metabolism


  • Amino Acids
  • Coordination Complexes
  • Metals
  • Peptides
  • Proteins
  • Gold