A Nonspecific Penile Ulcer Leading to the Diagnosis of Wegener's Granulomatosis

Urol J. 2020 Mar 16;17(2):210-212. doi: 10.22037/uj.v0i0.4526.

Abstract

The presented case describes a 53-year-old male who had been treated for non-specific cutaneous lesions for two months without any improvement. He was referred to our department after developing an erosive penile ulcer. Investigation for sexually transmitted diseases and Mycobacterium tuberculosis ended with negative results. Penile ulcer biopsy suggested the diagnosis of Wegener's granulomatosis (WG). The patient presented with upper respiratory tract symptoms during this period. Measuring antineutrophil cytoplasmic antibodies (c-ANCA), confirmed the diagnosis. Immunosuppressive therapy was initiated and resulted in a favorable response.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Antineutrophil Cytoplasmic / blood*
  • Biopsy / methods*
  • Diagnosis, Differential
  • Granulomatosis with Polyangiitis* / blood
  • Granulomatosis with Polyangiitis* / diagnosis
  • Granulomatosis with Polyangiitis* / drug therapy
  • Granulomatosis with Polyangiitis* / physiopathology
  • Humans
  • Immunosuppressive Agents / administration & dosage*
  • Male
  • Methotrexate / administration & dosage*
  • Middle Aged
  • Penile Diseases* / immunology
  • Penile Diseases* / pathology
  • Penile Diseases* / therapy
  • Prednisolone / administration & dosage*
  • Treatment Outcome
  • Ulcer* / diagnosis
  • Ulcer* / pathology

Substances

  • Antibodies, Antineutrophil Cytoplasmic
  • Immunosuppressive Agents
  • Prednisolone
  • Methotrexate