Expression and metabolic activity of flavin-containing monooxygenase 1 in cynomolgus macaque kidney

Yasuhiro Uno; Makiko Shimizu; Hiromi Yoda; Hiroshi Yamazaki

doi:10.1111/jmp.12385

Expression and metabolic activity of flavin-containing monooxygenase 1 in cynomolgus macaque kidney

J Med Primatol. 2019 Feb;48(1):51-53. doi: 10.1111/jmp.12385. Epub 2018 Sep 25.

Authors

Yasuhiro Uno¹, Makiko Shimizu², Hiromi Yoda², Hiroshi Yamazaki²

Affiliations

¹ Shin Nippon Biomedical Laboratories, Ltd., Kainan, Japan.
² Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.

PMID: 30252147
DOI: 10.1111/jmp.12385

Abstract

Flavin-containing monooxygenase 1 (FMO1) largely remains to be characterized in cynomolgus macaque kidney. Immunoblotting showed expression of cynomolgus FMO1 in kidneys where activities of FMO1 (benzydamine N-oxygenation) were detected. No sex differences were observed in their contents or activities. These results suggest the functional role of cynomolgus FMO1 in kidney.

Keywords: drug-metabolizing enzyme activity; flavin-containing monooxygenase; immunoblotting; sex difference.

MeSH terms

Animals
Benzydamine / metabolism
Kidney / enzymology*
Macaca fascicularis / genetics*
Macaca fascicularis / metabolism
Oxygenases / genetics*
Oxygenases / metabolism

Substances

Benzydamine
Oxygenases
dimethylaniline monooxygenase (N-oxide forming)