Isoproterenol

Excerpt

Isoproterenol, also known as isoprenaline, is a nonselective beta-1 and beta-2 adrenergic receptor agonist primarily used in the management of bradydysrhythmias and for electrophysiologic evaluation in supervised clinical settings. The administration and postadministration monitoring of this drug are complex and require a coordinated interprofessional approach to ensure safe and effective use. Structurally similar to epinephrine, isoproterenol increases heart rate and myocardial contractility while producing peripheral vasodilation and bronchodilation. Approved by the US Food and Drug Administration (FDA) in 1947, isoproterenol has both FDA-approved and off-label clinical applications.