Cholestatic features in hepatitis A

J Hepatol. 1986;3(2):172-81. doi: 10.1016/s0168-8278(86)80023-x.


The clinical, biochemical and histological characteristics of 13 cases of acute hepatitis A were evaluated. In 10 biopsies moderate to severe cholestasis was seen consisting of bile thrombi, cholestatic liver cell rosettes and ductular transformation of hepatocytes as shown on keratin- and S-100 immunostaining. The periportal spotty necrosis may play a role in the pathogenesis of cholestasis in hepatitis A by creating an interruption in continuity of bile flow. In 6 cases, abnormal ductular epithelium was seen resembling the ductular lesion in septicemia. Such ductular lesion may be related to the accumulation of leucotrienes as a result of cholestasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Child
  • Cholestasis / etiology*
  • Cholestasis / pathology
  • Female
  • Hepatitis A / blood
  • Hepatitis A / complications*
  • Hepatitis A / immunology
  • Hepatitis A / pathology
  • Hepatitis Antibodies / analysis
  • Hepatovirus / immunology
  • Humans
  • Immunoglobulin M / analysis
  • Male
  • Middle Aged


  • Hepatitis Antibodies
  • Immunoglobulin M