An international multicentre prospective audit of elective rectal cancer surgery; operative approach versus outcome, including transanal total mesorectal excision (TaTME)

Colorectal Dis. 2018 Sep;20 Suppl 6:33-46. doi: 10.1111/codi.14376.

Abstract

Introduction: Transanal total mesorectal excision (TaTME) has rapidly emerged as a novel approach for rectal cancer surgery. Safety profiles are still emerging and more comparative data is urgently needed. This study aimed to compare indications and short-term outcomes of TaTME, open, laparoscopic, and robotic TME internationally.

Methods: A pre-planned analysis of the European Society of Coloproctology (ESCP) 2017 audit was performed. Patients undergoing elective total mesorectal excision (TME) for malignancy between 1 January 2017 and 15 March 2017 by any operative approach were included. The primary outcome measure was anastomotic leak.

Results: Of 2579 included patients, 76.2% (1966/2579) underwent TME with restorative anastomosis of which 19.9% (312/1966) had a minimally invasive approach (laparoscopic or robotic) which included a transanal component (TaTME). Overall, 9.0% (175/1951, 15 missing outcome data) of patients suffered an anastomotic leak. On univariate analysis both laparoscopic TaTME (OR 1.61, 1.02-2.48, P = 0.04) and robotic TaTME (OR 3.05, 1.10-7.34, P = 0.02) were associated with a higher risk of anastomotic leak than non-transanal laparoscopic TME. However this association was lost in the mixed-effects model controlling for patient and disease factors (OR 1.23, 0.77-1.97, P = 0.39 and OR 2.11, 0.79-5.62, P = 0.14 respectively), whilst low rectal anastomosis (OR 2.72, 1.55-4.77, P < 0.001) and male gender (OR 2.29, 1.52-3.44, P < 0.001) remained strongly associated. The overall positive circumferential margin resection rate was 4.0%, which varied between operative approaches: laparoscopic 3.2%, transanal 3.8%, open 4.7%, robotic 1%.

Conclusion: This contemporaneous international snapshot shows that uptake of the TaTME approach is widespread and is associated with surgically and pathologically acceptable results.

Keywords: TME; Rectal cancer; TaTME; laparoscopic surgery; robotic surgery; transanal TME.

Publication types

  • Multicenter Study

MeSH terms

  • Aged
  • Elective Surgical Procedures / methods
  • Elective Surgical Procedures / statistics & numerical data*
  • Female
  • Humans
  • Laparoscopy / methods
  • Laparoscopy / statistics & numerical data
  • Male
  • Margins of Excision
  • Medical Audit
  • Middle Aged
  • Operative Time
  • Postoperative Complications / etiology
  • Proctectomy / methods
  • Proctectomy / statistics & numerical data*
  • Prospective Studies
  • Rectal Neoplasms / surgery*
  • Rectum / surgery*
  • Robotic Surgical Procedures / methods
  • Robotic Surgical Procedures / statistics & numerical data
  • Transanal Endoscopic Surgery / methods
  • Transanal Endoscopic Surgery / statistics & numerical data*
  • Treatment Outcome