Effect of pea protein plus grape seed dry extract on a murine model of Candida albicans induced vaginitis

Future Microbiol. 2018 Sep:13:1375-1382. doi: 10.2217/fmb-2018-0102. Epub 2018 Sep 26.


Aim: The objective of this research was to evaluate the antifungal properties of the association between grape seed and pea by using a nonpharmacological medical device that contains them.

Materials & methods: A murine model of vulvovaginal candidiasis, induced by Candida albicans infection, was used.

Results: We showed that topical treatment with the device significantly reduced the fungal burden in vagina and preserved vagina tissue architecture from C. albicans infection.

Conclusion: We can support the potential beneficial effect of the association between grape and pea extract present in the medical device. Together these results supported this device as a favorable antifungal agent and a promising synergist with fluconazole in the clinical management of vulvovaginal candidiasis caused by C. albicans biofilms.

Keywords: fluconazole; grape seed extract; pea protein; vaginitis.

MeSH terms

  • Animals
  • Antifungal Agents / administration & dosage*
  • Antifungal Agents / chemistry
  • Biofilms
  • Candida albicans / drug effects*
  • Candida albicans / physiology
  • Candidiasis, Vulvovaginal / drug therapy*
  • Candidiasis, Vulvovaginal / microbiology
  • Disease Models, Animal
  • Drug Synergism
  • Female
  • Fluconazole / administration & dosage
  • Humans
  • Mice
  • Pea Proteins / administration & dosage*
  • Pea Proteins / chemistry
  • Plant Extracts / administration & dosage*
  • Plant Extracts / chemistry
  • Seeds / chemistry
  • Vaginitis / drug therapy*
  • Vaginitis / microbiology
  • Vitis / chemistry*


  • Antifungal Agents
  • Pea Proteins
  • Plant Extracts
  • Fluconazole