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. 2018 Oct 10;16(39):7139-7142.
doi: 10.1039/c8ob01773e.

A Pendant Peptide Endows a Sunscreen With Water-Resistance

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Free PMC article

A Pendant Peptide Endows a Sunscreen With Water-Resistance

Aubrey J Ellison et al. Org Biomol Chem. .
Free PMC article

Abstract

Ultraviolet light causes skin cancer. Salicylic acid and other molecular filters absorb damaging radiation but are washed away readily. Conjugation to a collagen mimetic peptide is shown to retain salicylic acid on collagen-containing skin surrogates after repeated washing. This strategy, which is highly modular, could enhance the water-resistance of sunscreens.

Conflict of interest statement

Conflicts of interest

There are no conflicts to declare.

Figures

Fig. 1
Fig. 1
Structures of salicylic acid, its CMP conjugate (Sal-lCMP), and related molecules used in this work.
Fig. 2
Fig. 2
UV spectra of solutions of Sal-lCMP and related analytes (10 µM) in methanol.
Fig. 3
Fig. 3
Graph showing the adherence of Red-lCMP and Red-dCMP to collagen-coated wells after a series of washes. Fluorescence was measured with ex: 560 nm and em: 580 nm, and values are the mean ± SD from triplicate measurements. (For experimental details, see: Supplementary Information, Section IV.)
Fig. 4
Fig. 4
Images showing the adherence of CMP conjugates and related analytes to collagen surfaces, before and after washing. (A) Photographs of cyanotype paper after being covered by collagen-coated wells that had been treated with Sal-lCMP or a related analyte. (B) Top, Inverse-fluorescence images of Vitro-skin® spotted with 5 µL of an aqueous solution of Red-lCMP or Red-dCMP (16→0.25 mM). Bottom, Graph of the data as quantified with ImageJ software. For experimental details, see: Supplementary Information, Sections IV–VI.
Fig. 5
Fig. 5
Solid-state UV spectra of Vitro-skin® treated with a methanolic solution of Sal-lCMP and 2-ethylhexyl salicylate at 0.14 µmol/cm2.
Fig. 6
Fig. 6
Graph showing the adherence of Sal-lCMP and 2-ethylhexyl salicylate to Vitro-skin®, before and after washing. Absorbance was measured at 300 nm initially (A0) and after a wash (An), and values are the mean ± SD from triplicate measurements. For experimental details, see: Supplementary Information, Section VII.

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