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Randomized Controlled Trial
. 2018 Sep 26;13(9):e0203305.
doi: 10.1371/journal.pone.0203305. eCollection 2018.

Pulse Wave Velocity and Central Aortic Pressure in Systolic Blood Pressure Intervention Trial Participants

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Free PMC article
Randomized Controlled Trial

Pulse Wave Velocity and Central Aortic Pressure in Systolic Blood Pressure Intervention Trial Participants

Mark A Supiano et al. PLoS One. .
Free PMC article

Abstract

Arterial stiffness, typically assessed as the aortic pulse wave velocity (PWV), and central blood pressure levels may be indicators of cardiovascular disease (CVD) risk. This ancillary study to the Systolic Blood Pressure Intervention Trial (SPRINT) obtained baseline assessments (at randomization) of PWV and central systolic blood pressure (C-SBP) to: 1) characterize these vascular measurements in the SPRINT cohort, and 2) test the hypotheses that PWV and C-SBP are associated with glucose homeostasis and markers of chronic kidney disease (CKD). The SphygmoCor® CPV device was used to assess carotid-femoral PWV and its pulse wave analysis study protocol was used to obtain C-SBP. Valid results were obtained from 652 participants. Mean (±SD) PWV and C-SBP for the SPRINT cohort were 10.7 ± 2.7 m/s and 132.0 ± 17.9 mm Hg respectively. Linear regression analyses for PWV and C-SBP results adjusted for age, sex, and race/ethnicity in relation to several markers of glucose homeostasis and CKD did not identify any significant associations with the exception of a marginally statistically significant and modest association between PWV and urine albumin-to-creatinine ratio (linear regression estimate ± SE, 0.001 ± 0.0006; P-value 0.046). In a subset of SPRINT participants, PWV was significantly higher than in prior studies of normotensive persons, as expected. For older age groups in the SPRINT cohort (age > 60 years), PWV was compared with a reference population of hypertensive individuals. There were no compelling associations noted between PWV or C-SBP and markers of glucose homeostasis or CKD.

Clinical trial registration: NCT01206062.

Conflict of interest statement

Suzanne Oparil has received research grant support or support/reimbursement for travel to meetings or other, non-financial support from: Actelion Clinical Research/George Clinical; AstraZeneca AB; Bayer; Lundbeck; Novartis; Novo Nordisk; ROX Medical; and has consulted for: Actelion/George Clinical, Lundbeck and Novo Nordisk. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Figures

Fig 1
Fig 1. Least square means and 95% confidence intervals for pulse wave velocity and central aortic blood pressure: generalized linear models with adjustments for sex, race, and age.

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