The effect of economy type on demand and preference for cocaine and saccharin in rats

Drug Alcohol Depend. 2018 Nov 1:192:150-157. doi: 10.1016/j.drugalcdep.2018.08.005. Epub 2018 Sep 18.

Abstract

Background: Economy type is an important determinant of reinforcer value. This study investigated the effect of open and closed economies on demand and preference for cocaine and saccharin in rats.

Methods: In the first phase, rats were trained to lever press for cocaine infusions or saccharin. The number of presses required for each reinforcer increased across sessions. Cocaine and saccharin economy type was manipulated over groups by varying post-session availability of these reinforcers. One group of rats had three hours' post-session access to unlimited cocaine (open economy). A second group had three hours' post-session access to unlimited saccharin. A third group had no post-session access to either reinforcer (closed economy). In a second phase, rats in the three conditions could make mutually exclusive choices for cocaine or saccharin.

Results: Post-session access to saccharin caused saccharin demand to become more elastic. Post-session access to cocaine had no effect on demand for cocaine but made demand for saccharin more elastic. Results from the choice phase generally paralleled those from the demand phase, the main finding being that post-session saccharin access caused an increase in cocaine preference.

Conclusions: These results show that manipulating economy type can affect cocaine and non-drug reinforcers differently. Opening the saccharin economy decreased saccharin's value. Opening the cocaine economy did not decrease cocaine's value, but instead led to a devaluation of saccharin. These results suggest that cocaine choice may be determined not only by the reinforcers immediately available, but also by those reinforcers' broader contexts of availability.

Keywords: Choice; Cocaine; Demand; Economy type; Rats; Saccharin.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Behavior, Addictive / psychology*
  • Choice Behavior / drug effects
  • Choice Behavior / physiology*
  • Cocaine / administration & dosage*
  • Dopamine Uptake Inhibitors / administration & dosage
  • Male
  • Rats
  • Rats, Long-Evans
  • Saccharin / administration & dosage*
  • Self Administration

Substances

  • Dopamine Uptake Inhibitors
  • Saccharin
  • Cocaine