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. 2018 Dec;19(6):519-536.
doi: 10.1007/s10522-018-9775-3. Epub 2018 Sep 27.

Age-related Changes in Skeletal Muscle: Changes to Life-Style as a Therapy

Free PMC article

Age-related Changes in Skeletal Muscle: Changes to Life-Style as a Therapy

Rachel McCormick et al. Biogerontology. .
Free PMC article


As we age, there is an age-related loss in skeletal muscle mass and strength, known as sarcopenia. Sarcopenia results in a decrease in mobility and independence, as well as an increase in the risk of other morbidities and mortality. Sarcopenia is therefore a major socio-economical problem. The mechanisms behind sarcopenia are unclear and it is likely that it is a multifactorial condition with changes in numerous important mechanisms all contributing to the structural and functional deterioration. Here, we review the major proposed changes which occur in skeletal muscle during ageing and highlight evidence for changes in physical activity and nutrition as therapeutic approaches to combat age-related skeletal muscle wasting.

Keywords: Muscle wasting; Sarcopenia; Sarcopenic therapeutics; Skeletal muscle ageing.


Fig. 1
Fig. 1
Summary of changes that occur within the aged skeletal muscle and the role they play in sarcopenia

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