Botulinum Toxin Injection for Lower Face and Oral Cavity Raynaud Phenomenon After Mandibulectomy, Free Fibula Reconstruction, and Radiation Therapy

Ann Plast Surg. 2019 Jan;82(1):53-54. doi: 10.1097/SAP.0000000000001622.


Isolated lingual and lower face Raynaud phenomenon without primary Raynaud of the digits is a very rare condition associated with chemoradiation therapy (RT) in previous reports. The condition, which more commonly presents in patients with a history of Raynaud disease, is often self-limiting, but vasodilating agents and steroids have been suggested as possible treatment options. Spasmodic torticollis is a different, more common entity, also associated with history of RT or previous head and neck surgery. We present a rare case of a patient who developed Raynaud phenomenon of the lower face and tongue in the presence of spasmodic torticollis after mandibulectomy and free fibula reconstruction followed by RT to the oral cavity and neck. Possible causes, pathophysiologic mechanisms and treatment options are discussed. This is the first report of botulinum toxin treatment of isolated secondary Raynaud phenomenon of the lower face and tongue.

Publication types

  • Case Reports

MeSH terms

  • Bone Transplantation / adverse effects
  • Bone Transplantation / methods
  • Botulinum Toxins / administration & dosage*
  • Carcinoma, Squamous Cell / pathology
  • Carcinoma, Squamous Cell / radiotherapy
  • Carcinoma, Squamous Cell / surgery
  • Fibula / surgery
  • Follow-Up Studies
  • Humans
  • Male
  • Mandibular Neoplasms / pathology
  • Mandibular Neoplasms / radiotherapy
  • Mandibular Neoplasms / surgery*
  • Mandibular Osteotomy / adverse effects*
  • Mandibular Osteotomy / methods
  • Middle Aged
  • Neck Dissection / adverse effects
  • Neck Dissection / methods
  • Plastic Surgery Procedures / adverse effects*
  • Plastic Surgery Procedures / methods
  • Radiotherapy, Adjuvant / adverse effects
  • Radiotherapy, Adjuvant / methods
  • Raynaud Disease / drug therapy*
  • Raynaud Disease / etiology
  • Raynaud Disease / physiopathology
  • Risk Assessment
  • Torticollis / drug therapy*
  • Torticollis / etiology
  • Treatment Outcome


  • Botulinum Toxins